Guillermo De los Santos is a 36-year-old professional football player from URU. He currently plays for Defensor Sporting Montevideo, wearing the number 3 shirt. He plays primarily as a Defender. He stands at 180cm tall and weighs 75kg. His preferred foot is Right. His current market value is estimated at 150K €.

His most recent move was a from Coritiba PR to Defensor Sporting Montevideo on 2023-01-10.

Throughout the Uruguay Primera Division 2026, Guillermo De los Santos featured in 3 matches, averaging 0 tackles, 0 interceptions, and 0 clearances per game, while blocking 0 shots per game.