He currently plays for Fiorentina Women, wearing the number 22 shirt. At the international level, he represents Netherlands Women. He plays primarily as a Defender.

Throughout the Italian Serie A Women 2025-2026, Ilse van der Zanden featured in 15 matches, averaging 1 tackles, 0.7 interceptions, and 3.1 clearances per game, while blocking 0.3 shots per game.