He currently plays for Atletico Nacional Medellin Women, wearing the number 8 shirt. He plays primarily as a Defender. He stands at 156cm tall and weighs 56kg.

Throughout the Colombian Liga Betplay Femenina 2026, Melissa Moreno featured in 1 matches, averaging 0 tackles, 0 interceptions, and 0 clearances per game, while blocking 0 shots per game.