At the international level, he represents San Marino U21. He plays primarily as a Forward. His current market value is estimated at 50K €.

His most recent move was a from San Marino Academy U22 to SP Domagnano on 2025-08-11.

In the San Marino Campionato di Calcio 2025-2026 season, Simone Santi scored 2 goals and provided 0 assists across 18 appearances, averaging 0.1 goals per game with 0 shots attempted and 0 on target.